Synthesis, structures, and urease inhibitory activities of three copper(II) and zinc(II) complexes with 2-{[2-(2-hydroxyethylamino)ethylimino]methyl}-4-nitrophenol.
نویسندگان
چکیده
In order to explore novel urease inhibitors, three new mononuclear complexes of Cu(II) and Zn(II) with Schiff base 2-{[2-(2-hydroxyethylamino)ethylimino]methyl}-4-nitrophenol have been prepared and structurally characterized by X-ray crystallography. Among the three complexes, two Cu(II) complexes show strong urease inhibitory activities with the IC(50) values being much lower than that of the acetohydroxamic acid, while the Zn(II) complex shows no activity at the concentration of 100 microM.
منابع مشابه
Preparation of Zinc (II) and cadmium (II) complexes of the tetradentate Schiff base ligand 2-((E)-(2-(2-(pyridine-2-yl)- ethylthio)ethylimino)methyl)-4-bromophenol (PytBrsalH).
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عنوان ژورنال:
- European journal of medicinal chemistry
دوره 45 7 شماره
صفحات -
تاریخ انتشار 2010